r2rtf - Easily Create Production-Ready Rich Text Format (RTF) Tables and Figures
Create production-ready Rich Text Format (RTF) tables and figures with flexible format.
Last updated 16 days ago
10.82 score 78 stars 10 dependents 171 scripts 4.1k downloads
metalite.ae - Adverse Events Analysis Using 'metalite'
Analyzes adverse events in clinical trials using the 'metalite' data structure. The package simplifies the workflow to create production-ready tables, listings, and figures discussed in the adverse events analysis chapters of "R for Clinical Study Reports and Submission" by Zhang et al. (2022) <https://r4csr.org/>.
Last updated 2 months ago
cdiscclinical-trialsmetadata
9.45 score 18 stars 2 dependents 31 scripts 743 downloads
simtrial - Clinical Trial Simulation
Provides some basic routines for simulating a clinical trial. The primary intent is to provide some tools to generate trial simulations for trials with time to event outcomes. Piecewise exponential failure rates and piecewise constant enrollment rates are the underlying mechanism used to simulate a broad range of scenarios such as those presented in Lin et al. (2020) <doi:10.1080/19466315.2019.1697738>. However, the basic generation of data is done using pipes to allow maximum flexibility for users to meet different needs.
Last updated 2 days ago
cpp
9.30 score 21 stars 52 scripts 619 downloads
gsDesign2 - Group Sequential Design with Non-Constant Effect
The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.
Last updated 2 days ago
cpp
8.92 score 22 stars 186 scripts 733 downloads
metalite - ADaM Metadata Structure
A metadata structure for clinical data analysis and reporting based on Analysis Data Model (ADaM) datasets. The package simplifies clinical analysis and reporting tool development by defining standardized inputs, outputs, and workflow. The package can be used to create analysis and reporting planning grid, mock table, and validated analysis and reporting results based on consistent inputs.
Last updated 7 months ago
cdiscclinical-trialsmetadata
8.89 score 15 stars 5 dependents 57 scripts 251 downloads
forestly - Interactive Forest Plot
Interactive forest plot for clinical trial safety analysis using 'metalite', 'reactable', 'plotly', and Analysis Data Model (ADaM) datasets. Includes functionality for adverse event filtering, incidence-based group filtering, hover-over reveals, and search and sort operations. The workflow allows for metadata construction, data preparation, output formatting, and interactive plot generation.
Last updated 10 hours ago
7.59 score 14 stars 1 dependents 12 scripts 198 downloads
pkglite - Compact Package Representations
A tool, grammar, and standard to represent and exchange R package source code as text files. Converts one or more source packages to a text file and restores the package structures from the file.
Last updated 5 months ago
clinical-trialsectdpackaging-toolpharmaverse
6.75 score 29 stars 12 scripts 848 downloads
psm3mkv - Evaluate Partitioned Survival and State Transition Models
Fits and evaluates three-state partitioned survival analyses (PartSAs) and Markov models (clock forward or clock reset) to progression and overall survival data typically collected in oncology clinical trials. These model structures are typically considered in cost-effectiveness modeling in advanced/metastatic cancer indications. Muston (2024). "Informing structural assumptions for three state oncology cost-effectiveness models through model efficiency and fit". Applied Health Economics and Health Policy.
Last updated 10 months ago
6.43 score 10 stars 1 scripts 151 downloads
boxly - Interactive Box Plot
Interactive box plot using 'plotly' for clinical trial analysis.
Last updated 10 months ago
6.11 score 13 stars 5 scripts 217 downloads
gMCPLite - Lightweight Graph Based Multiple Comparison Procedures
A lightweight fork of 'gMCP' with functions for graphical described multiple test procedures introduced in Bretz et al. (2009) <doi:10.1002/sim.3495> and Bretz et al. (2011) <doi:10.1002/bimj.201000239>. Implements a flexible function using 'ggplot2' to create multiplicity graph visualizations. Contains instructions of multiplicity graph and graphical testing for group sequential design, described in Maurer and Bretz (2013) <doi:10.1080/19466315.2013.807748>, with necessary unit testing using 'testthat'.
Last updated 1 years ago
5.79 score 11 stars 14 scripts 231 downloads