Package: gsDesign2
Title: Group Sequential Design with Non-Constant Effect
Version: 1.1.8
Authors@R: c(
    person("Keaven", "Anderson", email = "keaven_anderson@merck.com", role = c("aut")),
    person("Yujie", "Zhao", email = "yujie.zhao@merck.com", role = c("aut", "cre")),
    person("Yilong", "Zhang", email = "elong0527@gmail.com", role = c("aut")),
    person("John", "Blischak", email = "jdblischak@gmail.com", role = c("aut")),
    person("Yihui", "Xie", email = "yihui.xie@merck.com", role = c("aut")),
    person("Nan", "Xiao", email = "nan.xiao1@merck.com", role = c("aut")),
    person("Jianxiao", "Yang", email = "yangjx@ucla.edu", role = c("aut")),
    person("Amin", "Shirazi", email = "ashirazist@gmail.com", role = c("ctb")),
    person("Ruixue", "Wang", email = "ruixue.wang@merck.com", role = c("ctb")),
    person("Yi", "Cui", email = "yi.cui@merck.com", role = c("ctb")),
    person("Ping", "Yang", email = "ping.yang1@merck.com", role = c("ctb")),
    person("Xin Tong", "Li", email = "xin.tong.li@merck.com", role = c("ctb")),
    person("Chenxiang", "Li", email = "chenxiang.li@merck.com", role = c("ctb")),
    person("Hiroaki", "Fukuda", email = "hiroaki.fukuda@merck.com", role = c("ctb")),
    person("Hongtao", "Zhang", email = "hongtao.zhang1@merck.com", role = c("ctb")),
    person("Yalin", "Zhu", email = "yalin.zhu@outlook.com", role = c("ctb")),
    person("Shiyu", "Zhang", email = "shiyu.zhang@merck.com", role = c("ctb")),
    person("Dickson", "Wanjau", email = "dickson.wanjau@merck.com", role = c("ctb")),
    person("Merck & Co., Inc., Rahway, NJ, USA and its affiliates", role = "cph",
           comment = c(ROR = "02891sr49"))
    )
Description: The goal of 'gsDesign2' is to enable fixed or group
        sequential design under non-proportional hazards. To enable
        highly flexible enrollment, time-to-event and time-to-dropout
        assumptions, 'gsDesign2' offers piecewise constant enrollment,
        failure rates, and dropout rates for a stratified population.
        This package includes three methods for designs: average hazard
        ratio, weighted logrank tests in Yung and Liu (2019)
        <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial
        flexibility on top of what is in the 'gsDesign' package is
        intended for selecting boundaries.
License: GPL-3
URL: https://merck.github.io/gsDesign2/,
        https://github.com/Merck/gsDesign2
BugReports: https://github.com/Merck/gsDesign2/issues
Encoding: UTF-8
Depends: R (>= 4.1.0)
Imports: corpcor, data.table, dplyr, gsDesign, gt, methods, mvtnorm,
        npsurvSS (>= 1.1.0), r2rtf, stats, survival, tibble, tidyr,
        utils, Rcpp
Suggests: covr, ggplot2, cowplot, kableExtra, knitr, rmarkdown,
        simtrial, testit (>= 1.0)
VignetteBuilder: knitr
LinkingTo: Rcpp
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.3
Config/pak/sysreqs: cmake make libicu-dev libuv1-dev libxml2-dev
        libssl-dev libnode-dev
Repository: https://merck.r-universe.dev
Date/Publication: 2026-06-24 15:03:57 UTC
RemoteUrl: https://github.com/merck/gsdesign2
RemoteRef: HEAD
RemoteSha: 68bc1ff178f6c54a23a5846f276ce52a2eac7d9b
NeedsCompilation: yes
Packaged: 2026-06-24 16:32:10 UTC; root
Author: Keaven Anderson [aut],
  Yujie Zhao [aut, cre],
  Yilong Zhang [aut],
  John Blischak [aut],
  Yihui Xie [aut],
  Nan Xiao [aut],
  Jianxiao Yang [aut],
  Amin Shirazi [ctb],
  Ruixue Wang [ctb],
  Yi Cui [ctb],
  Ping Yang [ctb],
  Xin Tong Li [ctb],
  Chenxiang Li [ctb],
  Hiroaki Fukuda [ctb],
  Hongtao Zhang [ctb],
  Yalin Zhu [ctb],
  Shiyu Zhang [ctb],
  Dickson Wanjau [ctb],
  Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] (ROR:
    <https://ror.org/02891sr49>)
Maintainer: Yujie Zhao <yujie.zhao@merck.com>