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  "Package": "gsDesign2",
  "Title": "Group Sequential Design with Non-Constant Effect",
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  "Authors@R": "c(\nperson(\"Keaven\", \"Anderson\", email = \"keaven_anderson@merck.com\", role = c(\"aut\")),\nperson(\"Yujie\", \"Zhao\", email = \"yujie.zhao@merck.com\", role = c(\"aut\", \"cre\")),\nperson(\"Yilong\", \"Zhang\", email = \"elong0527@gmail.com\", role = c(\"aut\")),\nperson(\"John\", \"Blischak\", email = \"jdblischak@gmail.com\", role = c(\"aut\")),\nperson(\"Yihui\", \"Xie\", email = \"yihui.xie@merck.com\", role = c(\"aut\")),\nperson(\"Nan\", \"Xiao\", email = \"nan.xiao1@merck.com\", role = c(\"aut\")),\nperson(\"Jianxiao\", \"Yang\", email = \"yangjx@ucla.edu\", role = c(\"aut\")),\nperson(\"Amin\", \"Shirazi\", email = \"ashirazist@gmail.com\", role = c(\"ctb\")),\nperson(\"Ruixue\", \"Wang\", email = \"ruixue.wang@merck.com\", role = c(\"ctb\")),\nperson(\"Yi\", \"Cui\", email = \"yi.cui@merck.com\", role = c(\"ctb\")),\nperson(\"Ping\", \"Yang\", email = \"ping.yang1@merck.com\", role = c(\"ctb\")),\nperson(\"Xin Tong\", \"Li\", email = \"xin.tong.li@merck.com\", role = c(\"ctb\")),\nperson(\"Chenxiang\", \"Li\", email = \"chenxiang.li@merck.com\", role = c(\"ctb\")),\nperson(\"Hiroaki\", \"Fukuda\", email = \"hiroaki.fukuda@merck.com\", role = c(\"ctb\")),\nperson(\"Hongtao\", \"Zhang\", email = \"hongtao.zhang1@merck.com\", role = c(\"ctb\")),\nperson(\"Yalin\", \"Zhu\", email = \"yalin.zhu@outlook.com\", role = c(\"ctb\")),\nperson(\"Shiyu\", \"Zhang\", email = \"shiyu.zhang@merck.com\", role = c(\"ctb\")),\nperson(\"Dickson\", \"Wanjau\", email = \"dickson.wanjau@merck.com\", role = c(\"ctb\")),\nperson(\"Merck & Co., Inc., Rahway, NJ, USA and its affiliates\", role = \"cph\",\ncomment = c(ROR = \"02891sr49\"))\n)",
  "Description": "The goal of 'gsDesign2' is to enable fixed or group\nsequential design under non-proportional hazards. To enable\nhighly flexible enrollment, time-to-event and time-to-dropout\nassumptions, 'gsDesign2' offers piecewise constant enrollment,\nfailure rates, and dropout rates for a stratified population.\nThis package includes three methods for designs: average hazard\nratio, weighted logrank tests in Yung and Liu (2019)\n<doi:10.1111/biom.13196>, and MaxCombo tests. Substantial\nflexibility on top of what is in the 'gsDesign' package is\nintended for selecting boundaries.",
  "License": "GPL-3",
  "URL": "https://merck.github.io/gsDesign2/,\nhttps://github.com/Merck/gsDesign2",
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  "Repository": "https://merck.r-universe.dev",
  "Date/Publication": "2026-11-04 13:51:11 UTC",
  "RemoteUrl": "https://github.com/merck/gsdesign2",
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    "User": "root"
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  "Author": "Keaven Anderson [aut],\nYujie Zhao [aut, cre],\nYilong Zhang [aut],\nJohn Blischak [aut],\nYihui Xie [aut],\nNan Xiao [aut],\nJianxiao Yang [aut],\nAmin Shirazi [ctb],\nRuixue Wang [ctb],\nYi Cui [ctb],\nPing Yang [ctb],\nXin Tong Li [ctb],\nChenxiang Li [ctb],\nHiroaki Fukuda [ctb],\nHongtao Zhang [ctb],\nYalin Zhu [ctb],\nShiyu Zhang [ctb],\nDickson Wanjau [ctb],\nMerck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] (ROR:\n<https://ror.org/02891sr49>)",
  "Maintainer": "Yujie Zhao <yujie.zhao@merck.com>",
  "_user": "merck",
  "_type": "src",
  "_file": "gsDesign2_1.2.0.9003.tar.gz",
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  "_expires": "2027-02-12T16:26:07.000Z",
  "_created": "2026-11-04T15:52:45.000Z",
  "_published": "2026-11-04T16:26:09.778Z",
  "_upstream": "https://github.com/merck/gsdesign2",
  "_status": "success",
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      "title": "Average hazard ratio under non-proportional hazards",
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      ]
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      "title": "Blinded estimation of average hazard ratio",
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      "title": "Convert summary table of a fixed or group sequential design object to a gt object",
      "topics": [
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        "as_gt.fixed_design_summary",
        "as_gt.gs_design_summary"
      ]
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      "title": "Write summary table of a fixed or group sequential design object to an RTF file",
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        "as_rtf.fixed_design_summary",
        "as_rtf.gs_design_summary"
      ]
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      "title": "Expected events observed under piecewise exponential model",
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        "expected_event"
      ]
    },
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      "title": "Predict time at which a targeted event count is achieved",
      "topics": [
        "expected_time"
      ]
    },
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      "title": "Fixed design under non-proportional hazards",
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        "fixed_design_ahr",
        "fixed_design_fh",
        "fixed_design_lf",
        "fixed_design_maxcombo",
        "fixed_design_mb",
        "fixed_design_milestone",
        "fixed_design_rd",
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      "title": "Bound summary table",
      "topics": [
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      ]
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