{
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  "Package": "gsDesign2",
  "Title": "Group Sequential Design with Non-Constant Effect",
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  "Authors@R": "c(\nperson(\"Keaven\", \"Anderson\", email = \"keaven_anderson@merck.com\", role = c(\"aut\")),\nperson(\"Yujie\", \"Zhao\", email = \"yujie.zhao@merck.com\", role = c(\"aut\", \"cre\")),\nperson(\"Yilong\", \"Zhang\", email = \"elong0527@gmail.com\", role = c(\"aut\")),\nperson(\"John\", \"Blischak\", email = \"jdblischak@gmail.com\", role = c(\"aut\")),\nperson(\"Yihui\", \"Xie\", email = \"yihui.xie@merck.com\", role = c(\"aut\")),\nperson(\"Nan\", \"Xiao\", email = \"nan.xiao1@merck.com\", role = c(\"aut\")),\nperson(\"Jianxiao\", \"Yang\", email = \"yangjx@ucla.edu\", role = c(\"aut\")),\nperson(\"Amin\", \"Shirazi\", email = \"ashirazist@gmail.com\", role = c(\"ctb\")),\nperson(\"Ruixue\", \"Wang\", email = \"ruixue.wang@merck.com\", role = c(\"ctb\")),\nperson(\"Yi\", \"Cui\", email = \"yi.cui@merck.com\", role = c(\"ctb\")),\nperson(\"Ping\", \"Yang\", email = \"ping.yang1@merck.com\", role = c(\"ctb\")),\nperson(\"Xin Tong\", \"Li\", email = \"xin.tong.li@merck.com\", role = c(\"ctb\")),\nperson(\"Chenxiang\", \"Li\", email = \"chenxiang.li@merck.com\", role = c(\"ctb\")),\nperson(\"Hiroaki\", \"Fukuda\", email = \"hiroaki.fukuda@merck.com\", role = c(\"ctb\")),\nperson(\"Hongtao\", \"Zhang\", email = \"hongtao.zhang1@merck.com\", role = c(\"ctb\")),\nperson(\"Yalin\", \"Zhu\", email = \"yalin.zhu@outlook.com\", role = c(\"ctb\")),\nperson(\"Shiyu\", \"Zhang\", email = \"shiyu.zhang@merck.com\", role = c(\"ctb\")),\nperson(\"Dickson\", \"Wanjau\", email = \"dickson.wanjau@merck.com\", role = c(\"ctb\")),\nperson(\"Merck & Co., Inc., Rahway, NJ, USA and its affiliates\", role = \"cph\",\ncomment = c(ROR = \"02891sr49\"))\n)",
  "Description": "The goal of 'gsDesign2' is to enable fixed or group\nsequential design under non-proportional hazards. To enable\nhighly flexible enrollment, time-to-event and time-to-dropout\nassumptions, 'gsDesign2' offers piecewise constant enrollment,\nfailure rates, and dropout rates for a stratified population.\nThis package includes three methods for designs: average hazard\nratio, weighted logrank tests in Yung and Liu (2019)\n<doi:10.1111/biom.13196>, and MaxCombo tests. Substantial\nflexibility on top of what is in the 'gsDesign' package is\nintended for selecting boundaries.",
  "License": "GPL-3",
  "URL": "https://merck.github.io/gsDesign2/,\nhttps://github.com/Merck/gsDesign2",
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  "Repository": "https://merck.r-universe.dev",
  "Date/Publication": "2026-05-28 20:48:07 UTC",
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  "Author": "Keaven Anderson [aut],\nYujie Zhao [aut, cre],\nYilong Zhang [aut],\nJohn Blischak [aut],\nYihui Xie [aut],\nNan Xiao [aut],\nJianxiao Yang [aut],\nAmin Shirazi [ctb],\nRuixue Wang [ctb],\nYi Cui [ctb],\nPing Yang [ctb],\nXin Tong Li [ctb],\nChenxiang Li [ctb],\nHiroaki Fukuda [ctb],\nHongtao Zhang [ctb],\nYalin Zhu [ctb],\nShiyu Zhang [ctb],\nDickson Wanjau [ctb],\nMerck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] (ROR:\n<https://ror.org/02891sr49>)",
  "Maintainer": "Yujie Zhao <yujie.zhao@merck.com>",
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    "ahr_blinded",
    "as_gt",
    "as_rtf",
    "define_enroll_rate",
    "define_fail_rate",
    "expected_accrual",
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    "gs_info_wlr",
    "gs_power_ahr",
    "gs_power_combo",
    "gs_power_npe",
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    "gs_spending_combo",
    "gs_update_ahr",
    "ppwe",
    "pw_info",
    "s2pwe",
    "sequential_pval",
    "text_summary",
    "to_integer",
    "wlr_weight_1",
    "wlr_weight_fh",
    "wlr_weight_mb",
    "wlr_weight_n"
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      "page": "ahr",
      "title": "Average hazard ratio under non-proportional hazards",
      "topics": [
        "ahr"
      ]
    },
    {
      "page": "ahr_blinded",
      "title": "Blinded estimation of average hazard ratio",
      "topics": [
        "ahr_blinded"
      ]
    },
    {
      "page": "as_gt",
      "title": "Convert summary table of a fixed or group sequential design object to a gt object",
      "topics": [
        "as_gt",
        "as_gt.fixed_design_summary",
        "as_gt.gs_design_summary"
      ]
    },
    {
      "page": "as_rtf",
      "title": "Write summary table of a fixed or group sequential design object to an RTF file",
      "topics": [
        "as_rtf",
        "as_rtf.fixed_design_summary",
        "as_rtf.gs_design_summary"
      ]
    },
    {
      "page": "define_enroll_rate",
      "title": "Define enrollment rate",
      "topics": [
        "define_enroll_rate"
      ]
    },
    {
      "page": "define_fail_rate",
      "title": "Define failure rate",
      "topics": [
        "define_fail_rate"
      ]
    },
    {
      "page": "expected_accrual",
      "title": "Piecewise constant expected accrual",
      "topics": [
        "expected_accrual"
      ]
    },
    {
      "page": "expected_event",
      "title": "Expected events observed under piecewise exponential model",
      "topics": [
        "expected_event"
      ]
    },
    {
      "page": "expected_time",
      "title": "Predict time at which a targeted event count is achieved",
      "topics": [
        "expected_time"
      ]
    },
    {
      "page": "fixed_design",
      "title": "Fixed design under non-proportional hazards",
      "topics": [
        "fixed_design_ahr",
        "fixed_design_fh",
        "fixed_design_lf",
        "fixed_design_maxcombo",
        "fixed_design_mb",
        "fixed_design_milestone",
        "fixed_design_rd",
        "fixed_design_rmst"
      ]
    },
    {
      "page": "gs_b",
      "title": "Default boundary generation",
      "topics": [
        "gs_b"
      ]
    },
    {
      "page": "gs_bound_summary",
      "title": "Bound summary table",
      "topics": [
        "gs_bound_summary"
      ]
    },
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      "title": "Conditional power computation with non-constant effect size for non-/crossing an upper boundary at analysis j given observed Z value at analysis i",
      "topics": [
        "gs_cp"
      ]
    },
    {
      "page": "gs_cp_simple",
      "title": "Simple conditional power computation with non-constant effect size",
      "topics": [
        "gs_cp_simple"
      ]
    },
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      "page": "gs_create_arm",
      "title": "Create npsurvSS arm object",
      "topics": [
        "gs_create_arm"
      ]
    },
    {
      "page": "gs_design_ahr",
      "title": "Calculate sample size and bounds given targeted power and Type I error in group sequential design using average hazard ratio under non-proportional hazards",
      "topics": [
        "gs_design_ahr"
      ]
    },
    {
      "page": "gs_design_combo",
      "title": "Group sequential design using MaxCombo test under non-proportional hazards",
      "topics": [
        "gs_design_combo"
      ]
    },
    {
      "page": "gs_power_design_npe",
      "title": "Group sequential design computation with non-constant effect and information.",
      "topics": [
        "gs_design_npe",
        "gs_power_design_npe",
        "gs_power_npe"
      ]
    },
    {
      "page": "gs_design_rd",
      "title": "Group sequential design of binary outcome measuring in risk difference",
      "topics": [
        "gs_design_rd"
      ]
    },
    {
      "page": "gs_design_wlr",
      "title": "Group sequential design using weighted log-rank test under non-proportional hazards",
      "topics": [
        "gs_design_wlr"
      ]
    },
    {
      "page": "gs_info_ahr",
      "title": "Information and effect size based on AHR approximation",
      "topics": [
        "gs_info_ahr"
      ]
    },
    {
      "page": "gs_info_combo",
      "title": "Information and effect size for MaxCombo test",
      "topics": [
        "gs_info_combo"
      ]
    },
    {
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      "title": "Information and effect size under risk difference",
      "topics": [
        "gs_info_rd"
      ]
    },
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