{
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  "Title": "Lightweight Graph Based Multiple Comparison Procedures",
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  "Authors@R": "c(\nperson(\"Yalin\", \"Zhu\", email = \"yalin.zhu@outlook.com\", role = \"aut\",\ncomment = c(ORCID = \"0000-0003-3830-8660\")),\nperson(\"Yilong\", \"Zhang\", email = \"elong0527@gmail.com\", role = \"aut\"),\nperson(\"Xuan\", \"Deng\", email = \"xuan.deng@merck.com\", role = \"aut\"),\nperson(\"Keaven\", \"Anderson\", email = \"keaven_anderson@merck.com\", role = c(\"aut\", \"cre\")),\nperson(\"Nan\", \"Xiao\", role = \"aut\", comment = c(ORCID = \"0000-0002-0250-5673\")),\nperson(\"Kornelius\", \"Rohmeyer\", email = \"rohmeyer@small-projects.de\", role = \"ctb\",\ncomment = \"gMCP author\"),\nperson(\"Florian\", \"Klinglmueller\", email = \"float@lefant.net\", role = \"ctb\",\ncomment = \"gMCP author\"),\nperson(\"gMCP project contributors\", role = \"cph\", comment = \"gMCP package\"),\nperson(\"Merck & Co., Inc., Rahway, NJ, USA and its affiliates\", role = \"cph\")\n)",
  "Description": "A lightweight fork of 'gMCP' with functions for graphical\ndescribed multiple test procedures introduced in Bretz et al.\n(2009) <doi:10.1002/sim.3495> and Bretz et al. (2011)\n<doi:10.1002/bimj.201000239>. Implements a flexible function\nusing 'ggplot2' to create multiplicity graph visualizations.\nContains instructions of multiplicity graph and graphical\ntesting for group sequential design, described in Maurer and\nBretz (2013) <doi:10.1080/19466315.2013.807748>, with necessary\nunit testing using 'testthat'.",
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  "Repository": "https://merck.r-universe.dev",
  "Date/Publication": "2026-03-10 18:34:18 UTC",
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  "Author": "Yalin Zhu [aut] (ORCID: <https://orcid.org/0000-0003-3830-8660>),\nYilong Zhang [aut],\nXuan Deng [aut],\nKeaven Anderson [aut, cre],\nNan Xiao [aut] (ORCID: <https://orcid.org/0000-0002-0250-5673>),\nKornelius Rohmeyer [ctb] (gMCP author),\nFlorian Klinglmueller [ctb] (gMCP author),\ngMCP project contributors [cph] (gMCP package),\nMerck & Co., Inc., Rahway, NJ, USA and its affiliates [cph]",
  "Maintainer": "Keaven Anderson <keaven_anderson@merck.com>",
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    "BauerEtAl2001",
    "bdiagNA",
    "bonferroni.test",
    "bonferroni.trimmed.simes.test",
    "BonferroniHolm",
    "BretzEtAl2009a",
    "BretzEtAl2009b",
    "BretzEtAl2009c",
    "BretzEtAl2011",
    "checkCorrelation",
    "cycleGraph",
    "edgeAttr",
    "edgeAttr<-",
    "Entangled1Maurer2012",
    "Entangled2Maurer2012",
    "fallback",
    "Ferber2011",
    "FerberTimeDose2011",
    "fixedSequence",
    "generalSuccessive",
    "generatePvals",
    "generateWeights",
    "getMatrices",
    "getMatrix",
    "getNodes",
    "getRejected",
    "getWeights",
    "getXCoordinates",
    "getYCoordinates",
    "gMCP",
    "gMCP.extended",
    "graph2matrix",
    "graphTest",
    "hGraph",
    "HommelEtAl2007",
    "HommelEtAl2007Simple",
    "HungEtWang2010",
    "HuqueAloshEtBhore2011",
    "improvedFallbackI",
    "improvedFallbackII",
    "improvedParallelGatekeeping",
    "joinGraphs",
    "matrix2graph",
    "MaurerEtAl1995",
    "nodeAttr",
    "nodeAttr<-",
    "parallelGatekeeping",
    "parametric.test",
    "permutations",
    "placeNodes",
    "plot",
    "print",
    "rejectNode",
    "replaceVariables",
    "setEdge",
    "setRejected<-",
    "setWeights",
    "simConfint",
    "simes.on.subsets.test",
    "simes.test",
    "simpleSuccessiveI",
    "simpleSuccessiveII",
    "subgraph",
    "substituteEps",
    "truncatedHolm",
    "WangTing2014"
  ],
  "_help": [
    {
      "page": "bdiagNA",
      "title": "Create a Block Diagonal Matrix with NA outside the diagonal",
      "topics": [
        "bdiagNA"
      ]
    },
    {
      "page": "bonferroni.test",
      "title": "Weighted Bonferroni-test",
      "topics": [
        "bonferroni.test"
      ]
    },
    {
      "page": "bonferroni.trimmed.simes.test",
      "title": "Trimmed Simes test for intersections of two hypotheses and otherwise weighted Bonferroni-test",
      "topics": [
        "bonferroni.trimmed.simes.test"
      ]
    },
    {
      "page": "checkCorrelation",
      "title": "Check correlation matrix",
      "topics": [
        "checkCorrelation"
      ]
    },
    {
      "page": "entangledMCP-class",
      "title": "Class entangledMCP",
      "topics": [
        "entangledMCP",
        "entangledMCP-class",
        "getMatrices",
        "getMatrices,entangledMCP-method",
        "getNodes,entangledMCP-method",
        "getRejected,entangledMCP-method",
        "getWeights,entangledMCP-method",
        "getXCoordinates,entangledMCP-method",
        "getYCoordinates,entangledMCP-method",
        "print,entangledMCP-method"
      ]
    },
    {
      "page": "exampleGraphs",
      "title": "Functions that create different example graphs",
      "topics": [
        "BauerEtAl2001",
        "BonferroniHolm",
        "BretzEtAl2009a",
        "BretzEtAl2009b",
        "BretzEtAl2009c",
        "BretzEtAl2011",
        "cycleGraph",
        "Entangled1Maurer2012",
        "Entangled2Maurer2012",
        "exampleGraphs",
        "fallback",
        "Ferber2011",
        "FerberTimeDose2011",
        "fixedSequence",
        "generalSuccessive",
        "HommelEtAl2007",
        "HommelEtAl2007Simple",
        "HungEtWang2010",
        "HuqueAloshEtBhore2011",
        "improvedFallbackI",
        "improvedFallbackII",
        "improvedParallelGatekeeping",
        "MaurerEtAl1995",
        "parallelGatekeeping",
        "simpleSuccessiveI",
        "simpleSuccessiveII",
        "truncatedHolm",
        "WangTing2014"
      ]
    },
    {
      "page": "generatePvals",
      "title": "generatePvals",
      "topics": [
        "generatePvals"
      ]
    },
    {
      "page": "generateWeights",
      "title": "generateWeights",
      "topics": [
        "generateWeights"
      ]
    },
    {
      "page": "gMCP",
      "title": "Graph based Multiple Comparison Procedures",
      "topics": [
        "gMCP"
      ]
    },
    {
      "page": "gMCP.extended",
      "title": "Graph based Multiple Comparison Procedures",
      "topics": [
        "gMCP.extended"
      ]
    },
    {
      "page": "gMCPResult-class",
      "title": "Class gMCPResult",
      "topics": [
        "getRejected,gMCPResult-method",
        "getWeights,gMCPResult-method",
        "gMCPResult",
        "gMCPResult-class",
        "plot,gMCPResult,ANY-method",
        "plot,gMCPResult-method",
        "print,gMCPResult-method"
      ]
    },
    {
      "page": "gPADInterim-class",
      "title": "Class gPADInterim",
      "topics": [
        "getRejected,gPADInterim-method",
        "getWeights,gPADInterim-method",
        "gPADInterim",
        "gPADInterim-class",
        "plot,gPADInterim-method",
        "print,gPADInterim-method"
      ]
    },
    {
      "page": "graphMCP-class",
      "title": "Class graphMCP",
      "topics": [
        "edgeAttr",
        "edgeAttr,graphMCP,character,character,character-method",
        "edgeAttr<-",
        "edgeAttr<-,graphMCP,character,character,character-method",
        "getMatrix",
        "getMatrix,graphMCP-method",
        "getNodes",
        "getNodes,graphMCP-method",
        "getRejected",
        "getRejected,graphMCP-method",
        "getWeights",
        "getWeights,graphMCP-method",
        "getXCoordinates",
        "getXCoordinates,graphMCP-method",
        "getYCoordinates",
        "getYCoordinates,graphMCP-method",
        "graphMCP",
        "graphMCP-class",
        "nodeAttr",
        "nodeAttr,graphMCP,character,character-method",
        "nodeAttr<-",
        "nodeAttr<-,graphMCP,character,character-method",
        "plot,graphMCP,ANY-method",
        "plot,graphMCP-method",
        "print,graphMCP-method",
        "setEdge",
        "setEdge,character,character,graphMCP,character-method",
        "setEdge,character,character,graphMCP,numeric-method",
        "setRejected<-",
        "setRejected<-,graphMCP-method",
        "setWeights",
        "setWeights,graphMCP-method"
      ]
    },
    {
      "page": "graphTest",
      "title": "Multiple testing using graphs",
      "topics": [
        "graphTest"
      ]
    },
    {
      "page": "hGraph",
      "title": "Create multiplicity graphs using ggplot2",
      "topics": [
        "hGraph"
      ]
    },
    {
      "page": "joinGraphs",
      "title": "Joins two graphMCP objects",
      "topics": [
        "joinGraphs"
      ]
    },
    {
      "page": "matrix2graph",
      "title": "Matrix2Graph and Graph2Matrix",
      "topics": [
        "graph2matrix",
        "matrix2graph"
      ]
    },
    {
      "page": "parametric.test",
      "title": "Weighted parametric test",
      "topics": [
        "parametric.test"
      ]
    },
    {
      "page": "permutations",
      "title": "Permutation for a design matrix",
      "topics": [
        "permutations"
      ]
    },
    {
      "page": "placeNodes",
      "title": "Placement of graph nodes",
      "topics": [
        "placeNodes"
      ]
    },
    {
      "page": "rejectNode",
      "title": "Rejects a node/hypothesis and updates the graph accordingly.",
      "topics": [
        "rejectNode"
      ]
    },
    {
      "page": "replaceVariables",
      "title": "Replaces variables in a general graph with specified numeric values",
      "topics": [
        "replaceVariables"
      ]
    },
    {
      "page": "simConfint",
      "title": "Simultaneous confidence intervals for sequentially rejective multiple test procedures",
      "topics": [
        "simConfint",
        "simConfint,graphMCP-method"
      ]
    },
    {
      "page": "simes.on.subsets.test",
      "title": "Simes on subsets, otherwise Bonferroni",
      "topics": [
        "simes.on.subsets.test"
      ]
    },
    {
      "page": "simes.test",
      "title": "Weighted Simes test",
      "topics": [
        "simes.test"
      ]
    },
    {
      "page": "subgraph",
      "title": "Get a subgraph",
      "topics": [
        "subgraph"
      ]
    },
    {
      "page": "substituteEps",
      "title": "Substitute Epsilon",
      "topics": [
        "substituteEps"
      ]
    },
    {
      "page": "weighted.test.functions",
      "title": "Weighted Test Functions for use with gMCP",
      "topics": [
        "weighted.test.functions"
      ]
    }
  ],
  "_pkglogo": "https://github.com/merck/gmcplite/raw/HEAD/man/figures/logo.png",
  "_readme": "https://github.com/merck/gmcplite/raw/HEAD/README.md",
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    "cpp11",
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      "source": "GraphicalMultiplicity.Rmd",
      "filename": "GraphicalMultiplicity.html",
      "title": "Graphical testing for group sequential design",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Overview",
        "Design",
        "Multiplicity diagram for hypothesis testing",
        "Group sequential designs for each hypothesis",
        "H1: OS, Subgroup",
        "H2: OS, All",
        "H3: PFS, Subgroup",
        "H4: PFS, All",
        "H5 and H6: ORR",
        "Design list",
        "Spending plan and spending time",
        "Results entry at time of analysis",
        "Timing of analyses and resulting event counts and spending times",
        "Nominal p-values for each analysis",
        "Testing hypotheses",
        "Compute sequential p-values for each hypothesis",
        "Evaluate hypothesis rejection using gMCPLite",
        "Verification of hypotheses rejected",
        "Multiplicity graph sequence from gMCPLite",
        "Comparison of sequential p-values to multiplicity graphs",
        "Bounds at final $\\alpha$ allocated for group sequential tests",
        "Session information",
        "References"
      ],
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      "headings": [
        "Introduction",
        "The basic graph layout",
        "Specifying hypothesis names and $\\alpha$-allocation",
        "Text formatting and location, ellipse size",
        "Using colors and legends",
        "Specifying the transition matrix between hypotheses",
        "References"
      ],
      "created": "2022-08-02 17:34:26",
      "modified": "2024-01-11 16:22:06",
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